Systematic Review of the Effects of Acupuncture on BMI, Triglycerides, TNF-α, and IL-6 in Obesity Management

Khairun Nisa; Endang Listyaningsih Suparyanti; Lilik Wijayanti Wisrowo

doi:10.59890/ijarss.v3i9.116

Authors

Khairun Nisa Universitas Sebelas Maret
Endang Listyaningsih Suparyanti Universitas Sebelas Maret
Lilik Wijayanti Wisrowo Universitas Sebelas Maret

DOI:

https://doi.org/10.59890/ijarss.v3i9.116

Keywords:

Acupuncture, IL-6, IMT, TNF-, Triglycerides

Abstract

Introduction: Obesity is a condition of excessive fat accumulation that has the potential to cause health problems. One of the safe and efficient adjuvant therapy for obesity is acupuncture with several techniques, such as manual acupuncture, laser acupuncture, electroacupuncture, and catgut implantation. The purpose of this systematic review is to determine the effect of acupuncture on body mass index (BMI), triglycerides (TG), tumor necrosis factor alpha (TNF-a), and interleukin 6 (IL-6) in obesity management.

Methods: This study was a systematic review with searches on PubMed and Scopus electronic database. Inclusion criteria were obese patients aged ≥18 years who received acupuncture treatment and reported improvements in BMI, TG, TNF-a, and IL-6; publication year 2014-2024; English language; randomized controlled trial (RCT) phase >3; and free full text. Results: A total of 8 articles and 767 respondents were involved in this systematic review. Acupuncture was shown to significantly reduce BMI, TG, TNF-a, and IL-6 in obese patients. Conclusion: Acupuncture was shown to significantly reduce BMI, TG, TNF-a, and IL-6 in obese patients.

References

Arismendi, E., Rivas, E., Agustí, A., Ríos, J., Barreiro, E., Vidal, J., & Rodriguez-Roisin, R. (2014). The systemic inflammome of severe obesity before and after bariatric surgery. PLoS ONE, 9(9). https://doi.org/10.1371/journal.pone.0107859

Berger, V. W., & Alperson, S. Y. (2009). A general framework for the evaluation of clinical trial quality. Reviews on recent clinical trials, 4(2), 79-88.

Chen, X., Huang, W., Wei, D., Ding, D. G., Jiao, Y., Pan, H. L., Jin, Y. T., Zheng, Y. W., Zhang, Y. J., Zhang, Y. R., Liu, Y. R., & Zhou, Z. Y. (2020). Clinical effect of catgut implantation at acupoints for the treatment of simple obesity: A multicentre randomized controlled trial. Medicine (United States), 99(48), E23390. https://doi.org/10.1097/MD.0000000000023390

D'hoedt, A., & Vanuytsel, T. (2023). Dumping syndrome after bariatric surgery: prevalence, pathophysiology and role in weight reduction-a systematic review. Acta Gastro-Enterologica Belgica, 86(3), 417-427.

Fernando, M. L. (2019). Gambaran citra tubuh pada wanita dewasa awal yang mengalami obesitas. Jurnal Ilmiah Psikologi Terapan, 7(1), 101–118. https://doi.org/10.22219/jipt.v7i1.6369

Firouzjaei, A., Li, G. C., Wang, N., Liu, W. X., & Zhu, B. M. (2016). Comparative evaluation of the therapeutic effect of metformin monotherapy with metformin and acupuncture combined therapy on weight loss and insulin sensitivity in diabetic patients. Nutrition and Diabetes, 6. https://doi.org/10.1038/nutd.2016.16

Garvey, W. T., Birkenfeld, A. L., Dicker, D., Mingrone, G., Pedersen, S. D., Satylganova, A., Skovgaard, D., Sugimoto, D., Jensen, C., & Mosenzon, O. (2020). Efficacy and safety of liraglutide 3.0 mg in individuals with overweight or obesity and type 2 diabetes treated with basal insulin: The SCALE insulin randomized controlled trial. Diabetes Care, 43(5), 1085–1093. https://doi.org/10.2337/dc19-1745

Hastuty, Y. D. (2018). Perbedaan kadar kolesterol orang yang obesitas dengan orang yang non obesitas. AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh, 1(2), 47-55.

He, J., Zhang, X., Qu, Y., Huang, H., Liu, X., Du, J., & Guo, S. (2015). Effect of Combined Manual Acupuncture and Massage on Body Weight and Body Mass Index Reduction in Obese and Overweight Women: A Randomized, Short-term Clinical Trial. JAMS Journal of Acupuncture and Meridian Studies, 8(2), 61–65. https://doi.org/10.1016/j.jams.2014.08.001

Holmbäck, U., Forslund, A., Grudén, S., Alderborn, G., Söderhäll, A., Hellström, P. M., & Lennernäs, H. (2020). Effects of a novel combination of orlistat and acarbose on tolerability, appetite, and glucose metabolism in persons with obesity. Obesity Science and Practice, 6(3), 313–323. https://doi.org/10.1002/osp4.405

Hung, Y. C., Hung, I. L., Hu, W. L., Tseng, Y. J., Kuo, C. E., Liao, Y. N., Wu, B. Y., Tsai, C. C., Tsai, P. Y., Chen, H. P., Huang, M. H., & Su, F. Y. (2016). Reduction in postpartum weight with laser acupuncture A randomized control trial. Medicine (United States), 95(34). https://doi.org/10.1097/MD.0000000000004716

Ismail, A. M. A. (2023). Lipid Profile Response to Acupuncture in Obese Patients with Subjective Tinnitus: a Randomized Controlled Trial. JAMS Journal of Acupuncture and Meridian Studies, 16(1), 11–19. https://doi.org/10.51507/j.jams.2023.16.1.11

Kalarchian, M. A., Marcus, M. D., Courcoulas, A. P., Cheng, Y., & Levine, M. D. (2014). Self-report of gastrointestinal side effects after bariatric surgery. Surgery for Obesity and Related Diseases, 10(6), 1202–1207. https://doi.org/10.1016/j.soard.2014.08.007

Kementerian Kesehatan Republik Indonesia. (2020). Riset Kesehatan Dasar 2018.

Lam, T. F., Lyu, Z., Wu, X., Wong, Y. P., Cao, P., Wong, E. Y., Hung, H. B., Zhang, S., Bian, Z., & Zhong, L. L. D. (2024). Electro-acupuncture for central obesity: a patient-assessor blinded, randomized sham-controlled clinical trial. BMC Complementary Medicine and Therapies, 24(1). https://doi.org/10.1186/s12906-024-04340-5

Masi, G., & Oroh, W. (2018). Hubungan Obesitas dengan Kejadian Diabetes Melitus di Wilayah Kerja Puskesmas Ranomut Kota Manado. Jurnal Keperawatan, 6.

Natalia, D., Hasibuan, P., & Hendro. (2015). Hubungan Obesitas dengan Kejadian Hipertensi di Kecamatan Sintang, Kalimantan Barat. Cermin Dunia Kedokteran, 42.

Neuhouser, M. L., Aragaki, A. K., Prentice, R. L., Manson, J. A. E., Chlebowski, R., Carty, C. L., Ochs-Balcom, H. M., Thomson, C. A., Caan, B. J., Tinker, L. F., Urrutia, R. P., Knudtson, J., & Anderson, G. L. (2015). Overweight, obesity, and postmenopausal invasive breast cancer risk: A secondary analysis of the women’s health initiative randomized clinical trials. JAMA Oncology, 1(5), 611–621. https://doi.org/10.1001/jamaoncol.2015.1546

Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., … Moher, D. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. I: PLoS Medicine (Bd. 18, Nummer 3). Public Library of Science. https://doi.org/10.1371/JOURNAL.PMED.1003583

Peña, A., Olson, M. L., Ayers, S. L., Sears, D. D., Vega-López, S., Colburn, A. T., & Shaibi, G. Q. (2023). Inflammatory Mediators and Type 2 Diabetes Risk Factors before and in Response to Lifestyle Intervention among Latino Adolescents with Obesity. Nutrients, 15(11). https://doi.org/10.3390/nu15112442

Phillips, V., & Barker, E. (2021). Systematic reviews: Structure, form and content. Journal of Perioperative Practice, 31(9), 349–353. https://doi.org/10.1177/1750458921994693

Razzaghi, M., Akbari, Z., Mokmeli, S., Razzaghi, Z., Rezaei-Tavirani, M., Afzalimehr, M., & Kamani, E. (2023). Laser Diode - GaAlAs Acupuncture in the Treatment of Central Obesity: a Randomized Clinical Trial. JAMS Journal of Acupuncture and Meridian Studies, 16(6), 255–262. https://doi.org/10.51507/j.jams.2023.16.6.255

Ruban, A., Stoenchev, K., Ashrafian, H., & Teare, J. (2019). Current treatments for obesity. Clinical Medicine, 19(3), 205–212. https://doi.org/10.7861/clinmedicine.19-3-205

Sebayang, R. G., Aditya, C., Abdurrohim, K., Lauwrence, B., Mihardja, H., Kresnawan, T., & Helianthi, D. R. (2020). Effects of Laser Acupuncture and Dietary Intervention on Key Obesity Parameters. Medical Acupuncture, 32(2), 108–115. https://doi.org/10.1089/acu.2019.1398

World Health Organization. (2021). Obesity and Overweight. World Health Organization.

Zhang, X., Li, Q., Yi, R., Xing, C., Jin, Y., Meng, J., Feng, J., Zhao, S., Liang, F., & Guo, T. (2023). Effect of catgut embedding at acupoints versus non-acupoints in abdominal obesity: a randomized clinical trial. Journal of Traditional Chinese Medicine, 43(4), 781–786. https://doi.org/10.19852/j.cnki.jtcm.20230608.002